Calexico Bus Station: Bus Routes from Los Angeles, California to Mexico and EUU
Located in Imperial County, California, Calexico is an important border city connecting the United States with Mexicali, Baja California. Its strategic location makes it a key point for passengers traveling between Southern California, Arizona and northwestern Mexico.
The Calexico Bus Station area serves several bus companies, although not all of them operate from traditional terminals. Greyhound has a physical station listed at 123 E 1st St, while TUFESA and Intercalifornias operate through buses coming from Los Angeles. These buses stop in Calexico to pick up passengers at designated local boarding points before continuing toward Mexico.
This distinction is important when planning a trip. TUFESA and Intercalifornias do not have conventional terminals with platforms in Calexico. Their local agencies sell tickets, while passengers board the buses at designated street-side locations or nearby meeting points.
Calexico is also a major connection for travelers heading to Mexicali and continuing toward Sonora, Sinaloa, Nayarit and Jalisco. Some services operate continuously on the same bus, while other journeys require a transfer in Mexicali.
Bus Stations and Bus Companies in Calexico
The Calexico Bus Station network includes a traditional Greyhound station and local ticket sales and boarding points used by companies traveling through the city from Los Angeles.
Greyhound Bus Station in Calexico
Address: 123 E 1st St, Calexico, CA 92231, United States
Phone: +1 800-231-2222
Website: https://www.greyhound.com/bus/calexico-ca/calexico-bus-station
Google Maps: https://maps.app.goo.gl/Y6vqjdEY64zrvQjM7
Greyhound is the only operator identified in this guide with a traditional bus station in Calexico. Its Google Maps listing places the station at 123 E 1st St, near the downtown commercial area and the international border.
Unlike the local agencies used by TUFESA and Intercalifornias, Greyhound has a formal passenger facility where travelers can access its bus services and check departure information.
Greyhound and FlixBus offer domestic connections toward destinations such as San Diego, Los Angeles and Phoenix. The company also provides a direct connection to Mexicali.
Passengers traveling farther into Mexico should be aware that Greyhound does not operate its own continuous bus service from Calexico to every Mexican destination. Many onward journeys require a transfer at the Central de Autobuses de Mexicali.
TUFESA in Calexico
TUFESA connects California with several destinations in northwestern and western Mexico. Its network includes routes to Sonora, Sinaloa, Nayarit and Jalisco.
In Calexico, TUFESA does not operate a traditional bus terminal with platforms. Its buses come from Los Angeles, travel through the Imperial Valley and pick up passengers at designated boarding points around E 1st St and Imperial Ave, close to the downtown pedestrian border crossing.
Local agencies and businesses may sell tickets, but these should not be confused with a formal bus station. Passengers need to confirm the precise boarding point before departure.
After picking up passengers in Calexico, the TUFESA bus continues toward Mexico. Selected Platinum services offer continuous long-distance journeys, allowing passengers to remain on the same vehicle beyond the border.
Website: https://tufesainternacional.com/
Intercalifornias in Calexico
Intercalifornias provides passenger transportation between California and destinations in the Mexican border region.
Its operation in Calexico is similar to TUFESA. The buses come from Los Angeles, travel through the region and pick up passengers at local ticket agencies or designated street-side boarding points around E 1st St and Imperial Ave.
Intercalifornias does not operate a traditional bus terminal with platforms in Calexico. Passengers should distinguish between the agency where they purchase their tickets and the actual place where the bus stops.
The company serves destinations including Los Angeles, San Ysidro, Mexicali and San Luis Río Colorado.
Direct Bus Routes from Calexico to the United States
The Calexico Bus Station area provides connections to several destinations within the United States. These domestic journeys do not require passengers to cross the international border into Mexico.
Bus from Calexico to San Diego and San Ysidro
Companies: Greyhound / FlixBus
Estimated travel time: 2 hours 15 minutes – 2 hours 45 minutes
Main route: I-8 West
San Diego and San Ysidro are important destinations for passengers traveling from the Imperial Valley toward Southern California.
San Ysidro is particularly useful for travelers who need to reach the international border crossing with Tijuana, while San Diego offers connections to other destinations throughout the region.
Bus from Calexico to Indio, San Bernardino and Los Angeles
Companies: Greyhound / FlixBus
Estimated travel time: 3 hours 30 minutes – 4 hours 30 minutes
Main route: CA-111 North and I-10 West
This route connects the Imperial Valley with destinations in Southern California, including Indio, San Bernardino and Los Angeles.
Los Angeles is an important transportation hub, offering connections to other cities throughout California and across the United States.
Passengers should check the arrival station shown on their ticket because different services may use different stops and terminals in Los Angeles.
Bus from Calexico to Yuma and Phoenix
Companies: Greyhound / FlixBus
Estimated travel time: Approximately 1 hour 30 minutes to Yuma and 4 hours 30 minutes to Phoenix
Main route: I-8 East
Yuma and Phoenix are important destinations for passengers traveling east from Calexico into Arizona.
Yuma is a regional stop along the route, while Phoenix provides connections to a wider network of destinations throughout the state and the southwestern United States.
Direct Bus Routes from Calexico to Mexico
One of the main reasons passengers use the Calexico Bus Station area is its proximity to Mexicali and the Mexican border.
However, the companies operating in Calexico have different route networks. Greyhound provides a direct connection to Mexicali, while TUFESA and Intercalifornias have services coming from Los Angeles that continue toward destinations in Mexico.
Bus from Calexico to Mexicali, Baja California
Companies: Greyhound, TUFESA and Intercalifornias
Border crossings: Calexico West or Calexico East
Mexicali is the main Mexican destination connected to Calexico. The two cities share an international border, making this one of the most convenient cross-border bus journeys in the region.
Greyhound offers a direct service to Mexicali. According to the route information used for this guide, the journey crosses the border and continues to the Central de Autobuses de Mexicali.
TUFESA and Intercalifornias also serve this corridor. Their buses arrive from Los Angeles, pick up passengers in Calexico and continue toward Mexico.
The border crossing used depends on the operator and the specific service. Calexico West is the downtown crossing, while Calexico East is located farther east of the city.
Bus from Calexico to San Luis Río Colorado, Sonora
Companies: TUFESA and Intercalifornias
San Luis Río Colorado is an important destination in northwestern Sonora, located southeast of Mexicali.
TUFESA and Intercalifornias provide connections toward this destination. Their buses come from Los Angeles, stop in Calexico to pick up passengers and continue toward Mexico.
Passengers should check the specific departure and ticket conditions to confirm the service and whether the same vehicle continues throughout the journey.
Bus from Calexico to Sonora
Company: TUFESA
TUFESA connects the California border region with several destinations in Sonora. Its services are particularly relevant for passengers traveling toward the interior of northwestern Mexico.
The main destinations include:
Caborca
Sonoyta
Hermosillo
Ciudad Obregón
Navojoa
Selected TUFESA International, Platinum and Titanium services operate toward these destinations.
The estimated journey time is approximately 10 hours to Caborca and 13 hours to Hermosillo, depending on the service and intermediate stops.
The buses come from Los Angeles, pick up passengers in Calexico and continue toward their destinations in Mexico. Selected services may allow passengers to complete the journey without changing buses.
Bus from Calexico to Sinaloa
Company: TUFESA
TUFESA connects the northwestern border region with several important destinations in Sinaloa.
The main destinations include:
Los Mochis
Guasave
Culiacán
Mazatlán
These destinations form part of the Pacific transportation corridor connecting northwestern Mexico with the rest of the country.
Selected continuous services may allow passengers boarding in Calexico to continue toward these destinations without changing buses. The exact arrangement depends on the departure and service category.
Bus from Calexico to Nayarit
Company: TUFESA
Passengers traveling toward Nayarit can look for connections to:
Acaponeta
Tecuala
Tepic
These destinations are part of the long-distance network connecting northwestern Mexico with western Mexico.
The estimated journey time for services reaching this part of the country is approximately 27–30 hours, depending on the destination and the number of stops.
Bus from Calexico to Guadalajara, Jalisco
Company: TUFESA
Guadalajara is one of the most important destinations in western Mexico. TUFESA offers selected Platinum and International services that can operate continuously toward the city.
The estimated journey time is approximately 32–34 hours, depending on the departure and route.
Passengers should pay particular attention to the service category when booking. Not every departure necessarily offers a continuous journey, so it is important to confirm that the same bus operates the entire route.
Bus Routes That Require a Transfer in Mexicali
Not all destinations in Mexico can be reached directly from Calexico with the same bus.
Greyhound does not operate its own long-distance bus routes from Calexico to the interior of Mexico. Passengers purchasing a ticket to destinations beyond Mexicali must change to a Mexican bus company at the Central de Autobuses de Mexicali.
This is particularly important for travelers heading toward Baja California, Sonora, Sinaloa, Nayarit, Jalisco and central Mexico.
Destinations Requiring a Transfer
Passengers traveling with Greyhound must transfer in Mexicali to continue toward the following destinations:
Baja California:
Sonora:
Sinaloa:
Nayarit:
Jalisco:
Guadalajara
Central and southern Mexico:
For the onward journey, passengers can use Mexican bus operators such as TAP, Elite, Ómnibus de México, ETN, Futura and ABC, depending on the destination and available departures.
It is important to distinguish these Greyhound connections from selected TUFESA Platinum services, which may continue beyond the border toward destinations in northwestern and western Mexico without requiring a change of vehicle.
Other Bus Stations in California
For more information about bus stations, bus companies and routes in California, explore the following city guides:
Bakersfield
El Centro
Fresno
Huntington Park
Los Angeles
Oxnard
Sacramento
San Bernardino
San Diego
San Ysidro
San Jose
Santa Ana
California Bus Stations
United States Bus Stations
How to Transfer at the Central de Autobuses de Mexicali
Passengers traveling beyond Mexicali with Greyhound should plan for a transfer to a Mexican bus company.
The usual process is:
Travel from Calexico to Mexicali using the booked Greyhound service.
Complete the relevant immigration and customs procedures.
Reach the Central de Autobuses de Mexicali.
Check the departure information for the Mexican bus company.
Board the next bus to the final destination.
Allow enough time between services because border inspections and the onward departure schedule can affect the connection.
Travel Tips for Passengers Using Calexico Bus Services
Before traveling from Calexico, consider these practical recommendations:
Check the Greyhound station address: Its Google Maps listing is at 123 E 1st St, Calexico.
Remember that TUFESA buses come from Los Angeles: They stop in Calexico to pick up passengers before continuing toward Mexico.
Remember that Intercalifornias buses also come from Los Angeles: Its local operation uses agencies and designated boarding points rather than a traditional terminal.
Confirm the boarding location: A ticket sales agency is not necessarily the place where the bus departs.
Verify direct services: Make sure the same physical bus continues to your destination if you want to avoid a transfer.
Allow time for border inspections: Immigration and customs procedures can affect the total journey.
Check onward connections in Mexicali: Greyhound passengers traveling beyond Mexicali need to confirm their Mexican bus company and departure.
Review your travel documents: Make sure you meet the entry and exit requirements for both countries.
Frequently Asked Questions About Calexico Bus Station
Where is the Greyhound bus station in Calexico?
The Google Maps listing identifies the Greyhound location at 123 E 1st St, Calexico, CA 92231. It is close to downtown Calexico and the international border.
Do TUFESA buses depart from a terminal in Calexico?
No traditional TUFESA terminal with platforms is identified in Calexico. Its buses come from Los Angeles, stop to pick up passengers at designated local boarding points around E 1st St and Imperial Ave, and continue toward Mexico.
Do Intercalifornias buses come from Los Angeles?
Yes. The services described in this guide arrive from Los Angeles, pick up passengers in Calexico at local boarding points and continue toward their destinations.
Can I travel directly from Calexico to Mexicali?
Yes. Greyhound, TUFESA and Intercalifornias are identified as operators serving the Calexico–Mexicali corridor. The exact boarding arrangements depend on the company and departure.
Can I travel directly from Calexico to Hermosillo?
TUFESA offers connections toward Hermosillo, including selected longer-distance services. The estimated journey time is approximately 13 hours. Passengers should verify the specific departure and whether the same bus continues throughout the journey.
Can I travel directly from Calexico to Guadalajara?
Selected TUFESA Platinum and International services may provide a continuous journey toward Guadalajara. The estimated journey time is approximately 32–34 hours. Confirm the service category before booking.
Do Greyhound buses from Calexico travel directly to Mexico City?
No. The Greyhound journey to Mexico City requires a transfer in Mexicali to a Mexican bus company.
Which bus companies operate in Calexico?
The main companies covered in this guide are Greyhound, FlixBus, TUFESA and Intercalifornias. Greyhound has a station listing in Calexico, while TUFESA and Intercalifornias use buses coming from Los Angeles and local boarding points.
Final Recommendations
Calexico is an important transportation point for passengers traveling between California, Arizona and Mexico. Its connection with Mexicali provides access to the northwestern Mexican bus network and onward journeys toward Sonora, Sinaloa, Nayarit and Jalisco.
The most important difference between the operators is how they serve the city. Greyhound has a traditional station listed at 123 E 1st St. TUFESA and Intercalifornias, on the other hand, operate buses coming from Los Angeles that stop in Calexico to pick up passengers at designated local boarding points before continuing toward Mexico.
For domestic journeys, passengers can look for Greyhound and FlixBus services toward San Diego, San Ysidro, Los Angeles, Yuma and Phoenix. For cross-border travel, Mexicali is the main connection. TUFESA is particularly relevant for longer-distance journeys into Mexico, while Greyhound passengers continuing beyond Mexicali should plan for a transfer to a Mexican operator.
Before booking, confirm the precise boarding location, the border crossing and whether your journey continues on the same physical bus. These details will help you choose the right service and avoid unexpected transfers along the way.
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